Author
University of ViennaORCID 0000-0001-7553-4806Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Maximilian W. G. Schneider, Marie S Polgar, Robert Kalis, Philip Barbulescu, Natalia Brunner, Mathias Madalinski, Dalia Barsyte-Lovejoy, Johannes A. Zuber, Manfred Koegl, Ralph A. Neumüller, Paola Martinelli
This study identifies BAP18 as a substrate of MAGE-A3/6, showing its degradation promotes cancer cell migration in both cell lines and human tissues.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology
Robert Kalis, Sumit Deswal, Markus Schäfer, Mathias Kalxdorf, Julian Jude, Jesse Lipp, Sarah Rieser, Vivien Vogt, Melanie de Almeida, Michaela Fellner, Stefanie Ruhland, Lisa Frasz, Florian Andersch, Jeroen Krijgsveld, Sebastian Carotta, Johannes A. Zuber
The paper uses CRISPR screens to identify regulators of immunosuppressive surface molecules in cancer cells, finding DNAJC13 as a key regulator that enhances T-cell sensitivity and tumor survival.
bioRxiv · Mar 11, 2026 · PreprintMolecular Biology
Hanna L. Brunner, Robert Kalis, Lorenz Grundmann, Zuzana Hodáková, Zuzana Koskova, Irina Grishkovskaya, Melanie de Almeida, Matthias Hinterndorfer, Hannah Knaudt, Simon Höfflin, Florian Andersch, Harald Kotisch, Achim Dickmanns, Sara Cuylen‐Haering, Johannes A. Zuber, David Haselbach
The paper identifies AKIRIN2 as a multivalent adaptor protein that coordinates proteasome nuclear import through a stepwise assembly of importin clusters.
Nature Communications · Feb 4, 2026Peer-reviewedMolecular Biology
Sascha Josef Amann, Robert Kalis, Maximilian Fottner, Hannah Knaudt, Irina Grishkovskaya, Johannes A. Zuber, Kathrin Lang, Nicholas Gene Brown, David Haselbach
The paper determines how the human 26S proteasome distinguishes between K48-linked and K11/K48-branched ubiquitin chains through structural analysis and functional studies.
bioRxiv · Apr 7, 2025 · PreprintBiochemistry
Tsimafei Navalayeu, Nikolaus Beer, Monika Bebjaková, Robert Kalis, Karel Stejskal, Gabriela Krššáková, Nina Fasching, Veronika A. Herzog, Niko P. Popitsch, Elisabeth Roitinger, Johannes A. Zuber, Stefan Ludwig Ameres
The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.
bioRxiv · Mar 14, 2025 · PreprintMolecular Biology