Incentive Salience, not Psychomotor Sensitization or Tolerance, Drives Escalation of Cocaine Self-Administration in Heterogeneous Stock Rats
Jarryd Ramborger, Joseph Mosquera, Molly Brennan, Benjamin C. Sichel, Dyar N. Othman, Sonja Lorean Plasil, Elizabeth A. Sneddon, Sélène Bonnet-Zahedi, Alex Morgan, Supakorn Chonwattanagul, Kathleen Bai, Lindsey China, Tu La, Lisa Maturin, Lieselot L. G. Carrette, Olivier George
The paper identifies incentive salience as the driver of cocaine self-administration escalation in rats, showing individual differences in pre-lever activity predict long-term intake.
Neuropsychopharmacology · Jan 17, 2026Peer-reviewedNeuroscience