Sélène Bonnet-Zahedi

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

The paper identifies incentive salience as the driver of cocaine self-administration escalation in rats, showing individual differences in pre-lever activity predict long-term intake.

This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.