Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Şeref Gül, Yasemin Kübra Akyel, Zeynep Melis Gül, Safak Isin, Onur Özcan, Tuba Korkmaz, Saba Selvi, İbrahim DANİŞ, Özgecan Şavluğ İpek, Fatih Aygenli, Ali Cihan Taşkın, Busra Aytul Akarlar, Nurhan Özlü, Nuri Öztürk, Narin Öztürk, , İbrahim Halil Kavaklı
The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.
Nature Communications · Nov 8, 2022Peer-reviewedMolecular Biology