Nurhan Özlü

Actinomycin D Drives RNA-Binding Proteins into Dynamic Cytoplasmic Granules

This study shows Act D causes RNA-binding proteins to redistribute to dynamic cytoplasmic granules, revealing a new cellular response to transcriptional inhibition.

A generalizable normalization framework to decouple protocol and instrument effects: Application to high-sensitivity proteomics multicentric study (PME13)

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

Keratin 16 spatially inhibits type I interferon responses in stressed and diseased skin

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

Proximity labeling reveals cell cycle-specific NEK2 interactions and a regulatory axis controlling NUSAP1 stability

The paper uses proximity labeling and mass spectrometry to map NEK2 interactions across the cell cycle, revealing a NEK2-NUSAP1 degradation pathway.

Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis

The paper shows that K15 promotes a progenitor cell state in skin epidermis by counteracting K14's suppression of YAP1, a Hippo signaling effector.

TW68, Cryptochromes stabilizer, regulates fasting blood glucose level in ob/ob and fat-induced diabetic mice

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of H3K79 methylation

This study identifies AF10 as a barrier to somatic cell reprogramming by regulating H3K79 methylation, showing that its suppression enhances reprogramming efficiency.

Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation

This study investigates the roles of three KIF2A isoforms in cortical neuron migration and differentiation, finding that two isoforms support radial migration while one is ineffective.

Terminal neuron localization to the upper cortical plate is controlled by the transcription factor NEUROD2

The paper identifies NEUROD2's role in terminal neuron localization during cortical development and reveals its regulation of the Reln gene.