İbrahim Halil Kavaklı

This paper develops a functional human retinohypothalamic tract assembloid to study circadian rhythms, showing synchronized network activity and self-sustained gene expression oscillations.

The paper analyzes PBMCs from astronauts before and during spaceflight to show microgravity induces telomere elongation, DNA repair activation, and miRNA suppression, suggesting a molecular longevity program in immune cells.

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

The paper determines the crystal structure of Vibrio cholerae (6-4) photolyase, revealing interactions with three cofactors and a potential DNA binding region.

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.