Author

Şeref Gül

Bezmiâlem Vakıf ÜniversitesiORCID 0000-0002-5613-1339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ali Cihan TaşkıniD· 2 shared Alper OkyariD· 2 shared Busra Aytul Akarlar· 2 shared İbrahim Halil KavaklıiD· 2 shared Metin TürkayiD· 2 shared Mustafa GüzeliD· 2 shared Nurhan ÖzlüiD· 2 shared Nuri ÖztürkiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Ali Cihan TaşkınORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 7, 2026

Phosphorylation-dependent Remodeling of the CLOCK/BMAL1/nucleosome Complex

Dima Amairy, Hanife Pekel, Şeref Gül, Özge Şensoy

This study investigates how phosphorylation affects the CLOCK/BMAL1/nucleosome complex through structural and mechanical changes, revealing its role in circadian transcriptional repression.

DOI 10.64898/2026.06.30.735537

protein structurestatistical model

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Molecular BiologybioRxivPreprintJul 13, 2023

TW68, Cryptochromes stabilizer, regulates fasting blood glucose level in ob/ob and fat-induced diabetic mice

Saliha Sürme, Cagla Ergun Ayva, Şeref Gül…·İbrahim Halil Kavaklı

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

1 citation

mouseexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedNov 8, 2022

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Şeref Gül, Yasemin Kübra Akyel, Zeynep Melis Gül…·İbrahim Halil Kavaklı

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

42 citationstop 4%

mouseexperimental assay

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