Author

Yasemin Kübra Akyel

Istanbul Medipol UniversityORCID 0000-0002-1734-8340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Ali Cihan TaşkıniD· 2 shared Alper OkyariD· 2 shared Busra Aytul Akarlar· 2 shared İbrahim Halil KavaklıiD· 2 shared Metin TürkayiD· 2 shared Mustafa GüzeliD· 2 shared Nurhan ÖzlüiD· 2 shared Nuri ÖztürkiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Ali Cihan TaşkınORCID

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Author profile →

3 papers

Recent·Most cited

Combinatorial Treatment of Glioblastoma with Temozolomide (TMZ) Plus 5-Ethynyl-2'-deoxyuridine (EdU)

Humeyra Kaanoglu, Yasemin Kübra Akyel, Adebimpe Adefolaju, Alain Valdivia, Dominique M. O. Higgins, Rani S. Sellers, Caroline Mosely, Corey J. Haswell, William C. Zamboni, Shawn Hingtgen, Andrew Satterlee, Aziz Sancar

This study evaluates the combination of TMZ and EdU in treating GBM, showing improved antitumor efficacy in vitro and in preclinical models.

Proceedings of the National Academy of Sciences · Dec 31, 2025Peer-reviewedCancer Biology

TW68, Cryptochromes stabilizer, regulates fasting blood glucose level in ob/ob and fat-induced diabetic mice

Saliha Sürme, Cagla Ergun Ayva, Şeref Gül, Yasemin Kübra Akyel, Zeynep Melis Gül, Onur Özcan, Özgecan Şavluğ İpek, Busra Aytul Akarlar, Nurhan Özlü, Ali Cihan Taşkın, Metin Türkay, Ahmet Ceyhan Gören, İbrahim Barış, Nuri Öztürk, Mustafa Güzel, , İbrahim Halil Kavaklı

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

bioRxiv · Jul 13, 2023 · PreprintMolecular Biology

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Şeref Gül, Yasemin Kübra Akyel, Zeynep Melis Gül, Safak Isin, Onur Özcan, Tuba Korkmaz, Saba Selvi, İbrahim DANİŞ, Özgecan Şavluğ İpek, Fatih Aygenli, Ali Cihan Taşkın, Busra Aytul Akarlar, Nurhan Özlü, Nuri Öztürk, Narin Öztürk, , İbrahim Halil Kavaklı

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

Nature Communications · Nov 8, 2022Peer-reviewedMolecular Biology