The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins
Adam M. Bayless, Lijiang Song, Mitchell Sorbello, Sam C. Ogden, Tyler S. Todd, Alice Flint, Natsumi Maruta, Jedidiah Tulu, Mikhail S. Drenichev, Vardis E. Ntoukakis, Thomas Ve, Mehdi Mobli, Li Wan, Qingli Liu, Jeffery L. Dangl, , Marc T. Nishimura
This study analyzes the TIRome of Arabidopsis to design artificial TIR proteins and identify functional polymorphisms that influence cell death and metabolite production.
Proceedings of the National Academy of Sciences · Sep 12, 2025Peer-reviewedPlant Biology