Li Wan

Conserved TIR-only proteins drive transcriptional defense and basal immunity in dicot and monocot plants

This study identifies conserved TIR-only proteins in dicots and monocots that promote basal immunity and transcriptional defense independently of NLR pathways.

Transition metal-triggered immunity via an Arabidopsis NLR pair

The paper shows that two Arabidopsis NLRs, STM1 and STM2, antagonistically regulate transition metal-triggered immunity, balancing pathogen resistance and metal toxicity.

The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins

This study analyzes the TIRome of Arabidopsis to design artificial TIR proteins and identify functional polymorphisms that influence cell death and metabolite production.

TIR immune signaling is blocked by phosphorylation to maintain plant growth

This study identifies phosphorylation of a conserved serine residue in TIR domains as a mechanism to block NADase activity and repress immune signaling, balancing growth and defense in plants and animals.