Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition
M. P. Bebelman, C. Crudden, B. Snieder, E. Thanou, C. J. M. Langedijk, M. Viola, S. Eleonora, U. Baginska, O. Cotugno, J. P. M. Bebelman, M. A. J. van Eijndhoven, L. Bosch, K. W. Li, M. J. Smit, G. van Niel, , D. M. Pegtel
This study identifies PI4KIIIβ as a key mediator of exosome secretion upon lysosome inhibition using a luminescence-based screening approach.
bioRxiv · Feb 23, 2023 · PreprintCell Biology