Author

D. M. Pegtel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. J. Verweij· 3 shared M. P. Bebelman· 2 shared M. Viola· 2 shared A. B. Smit· 1 shared A. Clayton· 1 shared A. Kutikhin· 1 shared A. Lobov· 1 shared A. N. Kapustin· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

F. J. Verweij

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Author profile →

3 papers

Recent·Most cited

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes

M. Viola, M. P. Bebelman, R. G. C. Maas, F. J. Verweij, C. S. Seinen, S. C. A. de Jager, P. Vader, D. M. Pegtel, J. P. G. Sluijter

This study investigates how hypoxia and TNF-alpha affect extracellular vesicle release from hiPSC-CMs under stress conditions, identifying nSmase2 and mTOR signaling pathways involved.

bioRxiv · Feb 1, 2024Cell Biology

Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.

A. N. Kapustin, S. S. Tsakali, M. Whitehead, G. Chennell, M.-Y. Wu, C. Molenaar, A. Kutikhin, Y. Chen, S. Ahmad, L. Bogdanov, M. Sinitsky, K. Rubina, A. Clayton, F. J. Verweij, D. M. Pegtel, , C. M. Shanahan

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

bioRxiv · Aug 17, 2023 · PreprintCell Biology

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

M. P. Bebelman, C. Crudden, B. Snieder, E. Thanou, C. J. M. Langedijk, M. Viola, S. Eleonora, U. Baginska, O. Cotugno, J. P. M. Bebelman, M. A. J. van Eijndhoven, L. Bosch, K. W. Li, M. J. Smit, G. van Niel, , D. M. Pegtel

This study identifies PI4KIIIβ as a key mediator of exosome secretion upon lysosome inhibition using a luminescence-based screening approach.

bioRxiv · Feb 23, 2023 · PreprintCell Biology