U. P. Neumann

KIF23 regulation by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

This study identifies miR-122's role in liver disease by showing its antagonistic effects on NRF1 and E2F4 and its impact on proteins linked to malignancy.

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

Rapid identification of optimal drug combinations for personalized cancer therapy using microfluidics

This paper presents a microfluidics-based method to rapidly screen drug combinations on patient cancer cells, identifying personalized treatment options validated in pancreatic cancer cell lines.