Identification of small molecule inhibitors of G3BP-driven stress granule formation
B. D. Freibaum, J. Messing, H. Nakamura, U. Yurtsever, J. Wu, H. J. Kim, J. Hixon, R. Lemieux, J. Duffner, W. Huynh, K. Wong, M. White, C. Lee, R. Meyers, R. D. Parker, J. P. Taylor
This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.
bioRxiv · Jun 27, 2023Cell Biology