Author

B. D. Freibaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. P. Taylor· 5 shared H. J. Kim· 3 shared J. Messing· 3 shared A. J. Gonzalez· 1 shared A. Ruggieri· 1 shared A. Y. Ting· 1 shared C. Brautigam· 1 shared C. Lee· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersCell Biology

J. P. Taylor

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Author profile →

5 papers

Recent·Most cited

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

M. Lopez-Nieto Jordana, Z. Sun, E. Relton, R. Safakli, B. D. Freibaum, J. P. Taylor, A. Ruggieri, I. Smyrnias, N. Locker

The paper shows that the mitochondrial unfolded protein response (UPRmt) interacts with stress granules (SGs) to regulate cellular stress responses and mitochondrial homeostasis.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

Identification of small molecule inhibitors of G3BP-driven stress granule formation

B. D. Freibaum, J. Messing, H. Nakamura, U. Yurtsever, J. Wu, H. J. Kim, J. Hixon, R. Lemieux, J. Duffner, W. Huynh, K. Wong, M. White, C. Lee, R. Meyers, R. D. Parker, J. P. Taylor

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

bioRxiv · Jun 27, 2023Cell Biology

Dynamic mapping of proteome trafficking within and between living cells by TransitID

W. Qin, J. S. Cheah, C. Xu, J. Messing, B. D. Freibaum, S. Boeynaems, J. P. Taylor, N. D. Udeshi, S. A. Carr, A. Y. Ting

TransitID maps proteome trafficking between cellular compartments and between cells with nanometer resolution, revealing new roles for stress granules and intercellular signaling.

bioRxiv · Feb 7, 2023Cell Biology

A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 is linked to neurodevelopmental disorders

A. J. Gonzalez, H. J. Kim, B. D. Freibaum, C. Brautigam, J. P. Taylor, Y. M. Chook

This study identifies a new Karyopherin-β2 binding epitope in HNRNPH2 linked to neurodevelopmental disorders, explaining cytoplasmic accumulation due to nuclear import defects.

bioRxiv · Jan 20, 2023Biophysics

High fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

B. D. Freibaum, J. Messing, H. J. Kim, J. P. Taylor

This paper introduces a system for high fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate, bridging in vitro and live cell studies of membraneless organelles.

bioRxiv · Sep 14, 2020Cell Biology