Structure and functional analysis of CDNF-BiP interaction reveal a role in endoplasmic reticulum proteostasis regulation
Satoshi Fudo, Olesya G. Shpironok, Oleksii Zdorevskyi, Urve Toots, Mart Ustav, Li-Ying Yu, Märt Saarma, Tommi Kajander
This study characterizes the CDNF-BiP interaction structurally and functionally, revealing CDNF's role as an antagonist of BiP nucleotide exchange and its neuroprotective effects.
bioRxiv · Jul 8, 2025 · PreprintBiochemistry