V. A. Maltsev

A novel conceptual model of heart rate autonomic modulation based on a small-world modular structure and heterogeneous innervation of the sinoatrial node

This paper proposes a new conceptual model of heart rate autonomic modulation based on modular structure and heterogeneous innervation of the sinoatrial node, showing how different cell clusters drive heart rate under varying conditions.

The paradigm shift: heartbeat initiation without the pacemaker cell

This paper challenges the traditional view of the pacemaker cell by showing that a network of dormant cells can generate rhythmic cardiac impulses through subthreshold signals and electrogenic exchange.

Adenosine Reduces Sinoatrial Node Cell AP Firing Rate by uncoupling its Membrane and Calcium Clocks

This study shows adenosine reduces sinoatrial node cell AP firing rate by uncoupling membrane and calcium clocks through Gi and Gβγ signaling.

Disorder in Ca2+ Release Unit Locations Confers Robustness but Cuts Flexibility of Heart Pacemaking

This study shows that disorder in Ca release unit positions in pacemaker cells creates release clusters that enhance pacemaking under low ICaL densities but reduce flexibility and β-adrenergic response.

Universal inverse square relationship between heart rate variability and heart rate

The paper derives an inverse square relationship between heart rate variability and heart rate, providing a formula to better interpret heart rate variability mechanisms at the cellular level.

β-adrenergic stimulation synchronizes a broad spectrum of action potential firing rates of cardiac pacemaker cells towards a higher population average

The study shows that β-adrenergic stimulation causes SAN cells to synchronize their firing rates towards a higher average, rather than uniformly increasing each cell's rate.

Self-similar synchronization of calcium and membrane potential transitions during AP cycles predict HR across species

The paper identifies self-similar scaling relationships between calcium and membrane potential kinetics in SAN cells across species, enabling prediction of heart rate and body mass.

Ca2+ and Membrane Potential Transitions During Action Potentials are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

The paper shows that Ca2+ and membrane potential transitions during action potentials in SAN cells are self-similar across species and autonomic stimulation, indicating long-range correlations in their kinetic behavior.

Synchronized cardiac impulses emerge from multi-scale, heterogeneous local calcium signals within and among cells of heart pacemaker tissue

This study reveals that cardiac action potentials arise from heterogeneous subcellular calcium signals in mouse sinoatrial node tissue, challenging the traditional model of uniform impulse generation.