E. G. Lakatta

A novel conceptual model of heart rate autonomic modulation based on a small-world modular structure and heterogeneous innervation of the sinoatrial node

This paper proposes a new conceptual model of heart rate autonomic modulation based on modular structure and heterogeneous innervation of the sinoatrial node, showing how different cell clusters drive heart rate under varying conditions.

The Therapeutic Effects of Long-term Photobiomodulation on Aging in Mice

This study shows that long-term photobiomodulation therapy improves healthspan and reduces age-related deterioration in mice.

Cardiomyocyte-specific adenylyl cyclase type-8 overexpression induces activation of RelA together with myocardial and systemic inflammation

This study shows that overexpressing adenylyl cyclase type-8 in cardiomyocytes activates RelA and causes myocardial and systemic inflammation, leading to accelerated aging and reduced lifespan.

Adenosine Reduces Sinoatrial Node Cell AP Firing Rate by uncoupling its Membrane and Calcium Clocks

This study shows adenosine reduces sinoatrial node cell AP firing rate by uncoupling membrane and calcium clocks through Gi and Gβγ signaling.

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

The Heart's Pacemaker Mimics Brain Cytoarchitecture and Function: Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node

This study describes the 3D cytoarchitecture of the sinoatrial node, revealing autonomic innervation, peripheral glial cells, and a novel S100B-expressing interstitial cell type that contribute to its structural and functional complexity.

Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice

This study tracks EKG recordings in mice to identify age-related changes in heart rhythm variability, linking them to signs of cardiac and systemic frailty in advanced age.

Cardiac adenylyl cyclase type 8 overexpression increases locomotor activity in mice by modulating EEG-gamma oscillations

This study shows that cardiac AC8 overexpression in mice increases locomotion via enhanced gamma oscillations linked to dopamine and GABA-A receptor activity.

β-adrenergic stimulation synchronizes a broad spectrum of action potential firing rates of cardiac pacemaker cells towards a higher population average

The study shows that β-adrenergic stimulation causes SAN cells to synchronize their firing rates towards a higher average, rather than uniformly increasing each cell's rate.

The Inflammatory Role of Milk Fat Globule Epidermal Growth Factor VIII in Angiotensin II Induced Arterial Remodeling

This study shows that MFG-E8 promotes Ang II-induced arterial inflammation and remodeling in aging, and its deficiency reduces these effects.

Self-similar synchronization of calcium and membrane potential transitions during AP cycles predict HR across species

The paper identifies self-similar scaling relationships between calcium and membrane potential kinetics in SAN cells across species, enabling prediction of heart rate and body mass.

Effects of Milk Fat Globule Epidermal Growth Factor VIII On Age-Associated Arterial Elastolysis, Fibrosis, and Calcification

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

Ca2+ and Membrane Potential Transitions During Action Potentials are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

The paper shows that Ca2+ and membrane potential transitions during action potentials in SAN cells are self-similar across species and autonomic stimulation, indicating long-range correlations in their kinetic behavior.

Synchronized cardiac impulses emerge from multi-scale, heterogeneous local calcium signals within and among cells of heart pacemaker tissue

This study reveals that cardiac action potentials arise from heterogeneous subcellular calcium signals in mouse sinoatrial node tissue, challenging the traditional model of uniform impulse generation.