Author

V. Alva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. N. Lupas· 2 shared A. von Kuegelgen· 2 shared S. van Dorst· 2 shared T. Bharat· 2 shared A. Bisson· 1 shared A. Cezanne· 1 shared A. Dobbelstein· 1 shared A. Dodge· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

A. N. Lupas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Halofilins as Emerging Bactofilin Families of Archaeal Cell Shape Plasticity Orchestrators

Z. Curtis, P. Escudeiro, J. L. Mallon, O. Leland, T. Rados, A. Dodge, K. Andre, J. Kwak, K. Yun, B. Isaac, M. Martinez Pastor, A. Schmid, M. Pohlschroder, V. Alva, A. Bisson

This study identifies and characterizes two new families of archaeal bactofilins, HalA and HalB, showing their roles in shaping cell morphology and curvature in Haloferax volcanii.

bioRxiv · Jan 22, 2024Microbiology

Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans

A. von Kuegelgen, S. van Dorst, K. Yamashita, D. L. Sexton, E. I. Tocheva, G. N. Murshudov, V. Alva, T. Bharat

This study reveals the structure of the hyperstable S-layer in Deinococcus radiodurans, showing it is formed by immunoglobulin-like HPI proteins arranged in a hexagonal lattice.

bioRxiv · Sep 15, 2022Microbiology

A multi-domain connector links the outer membrane and cell wall in deep-branching bacteria

A. von Kuegelgen, S. van Dorst, V. Alva, T. Bharat

This paper identifies a multi-domain connector protein in D. radiodurans that links the outer membrane to the cell wall, revealing its structural and evolutionary significance in bacterial envelope organization.

bioRxiv · May 18, 2022 · PreprintMicrobiology

Architecture of the biofilm-associated archaic CupE pilus from Pseudomonas aeruginosa

J. Boehning, A. Dobbelstein, N. Sulkowski, K. Eilers, A. von Kugelgen, A. K. Tarafder, V. Alva, A. Filloux, T. A. M. Bharat

This study presents the structure of the archaic CupE pilus from Pseudomonas aeruginosa, revealing its zigzag architecture and role in biofilm formation.

bioRxiv · Apr 14, 2022Microbiology

Structural diversity of oligomeric β-propellers with different numbers of identical blades

E. Afanasieva, I. Chaudhuri, J. Martin, E. Hertle, A. Ursinus, V. Alva, M. D. Hartmann, A. N. Lupas

The paper investigates the structural diversity of oligomeric β-propellers formed from different numbers of identical blades and finds they can fold as homo-oligomers.

bioRxiv · Aug 2, 2019Biochemistry

Allosteric structural alterations and auto-regulation of Rab5 GEF activity in Rabex5

J. Lauer, A. Cezanne, G. Guaitoli, F. Raimondi, M. Gentzel, V. Alva, M. Habeck, M. Ueffing, A. N. Lupas, C. J. Gloeckner, M. Zerial

This study reevaluates the autoinhibition mechanism of Rabex5 by analyzing structural changes and nucleotide exchange activity, revealing new regulatory roles for Ubiquitin binding domains.

bioRxiv · Feb 27, 2019 · PreprintBiophysics

Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata

M. L. Brault, J. D. Petit, F. Immel, W. J. Nicolas, L. Brocard, A. Gaston, M. Fouche, T. J. Hawkins, J.-M. Crowet, M. S. Grison, M. Kraner, V. Alva, S. Claverol, M. Deleu, L. Lins, , E. E. Bayer

This study identifies MCTPs as ER-PM tethers at plasmodesmata, linking membrane tethering to cell-to-cell signaling in plants.

bioRxiv · Sep 23, 2018Plant Biology