Author

V. Bottino-Rojas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

O. A. C. Talyuli· 3 shared A. B. Walter-Nuno· 2 shared G. Dimopoulos· 2 shared G. O. Paiva-SIlva· 2 shared J. H. M. Oliveira· 2 shared P. L. Oliveira· 2 shared A. A. James· 1 shared A. Buchman· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

O. A. C. Talyuli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CRISPR Mediated Transactivation in the Human Disease Vector Aedes aegypti

M. Bui, E. D. Benetta, Y. Dong, Y. Zhao, T. Yang, M. Li, I. A. Antoshechkin, A. Buchman, V. Bottino-Rojas, A. A. James, M. W. Perry, G. Dimopoulos, O. Akbari

This paper develops a CRISPRa system in Aedes aegypti to transactivate endogenous genes, demonstrating its ability to overexpress developmental genes and suppress dengue virus.

bioRxiv · Aug 31, 2022Bioengineering

An Aedes aegypti seryl-tRNA synthetase paralog controls bacteroidetes growth in the midgut

G. d. O. Silveira, O. A. C. Talyuli, A. B. Walter-Nuno, A. Crnkovic, A. C. P. Gandara, A. Gaviraghi, V. Bottino-Rojas, D. Söll, C. Polycarpo

This study shows that AaeSLIMP in Aedes aegypti controls Bacteroidetes growth in the midgut, affecting Zika virus prevalence through ROS production and dysbiosis.

bioRxiv · Aug 25, 2022 · PreprintBiochemistry

The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme induced peroxidase.

O. A. C. Talyuli, J. H. M. Oliveira, V. Bottino-Rojas, G. O. Silveira, P. H. Alvarenga, A. M. Kantor, G. O. Paiva-SIlva, C. Barillas-Mury, P. L. Oliveira

This study identifies HPx1, a heme-induced peroxidase in Aedes aegypti, which regulates the peritrophic matrix and influences vector competence for arboviruses by modulating ROS and microbiota.

bioRxiv · Jun 2, 2022Microbiology

Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus

M. L. Taracena, V. Bottino-Rojas, O. A. C. Talyuli, A. B. Walter-Nuno, J. H. M. Oliveira, Y. I. Anglero-Rodriguez, M. B. Wells, G. Dimopoulos, P. L. Oliveira, G. O. Paiva-Silva

This study investigates how midgut cell proliferation in Aedes aegypti affects susceptibility to dengue virus, showing that regenerative responses and Delta/Notch signaling influence vector competence.

bioRxiv · Feb 24, 2018Cell Biology