Multivalent interactions essential for lentiviral integrase function
A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov
This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.
bioRxiv · Jan 26, 2022Biochemistry