Author

D. T. Gruszka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Organism:Xenopus· 1

Frequent Co-Authors

H. Yardimci· 2 shared A. Ballandras-Colas· 1 shared A. N. Engelman· 1 shared A. Nans· 1 shared D. J. Griffiths· 1 shared D. Lyumkis· 1 shared E. M. Poeschla· 1 shared G. J. Bedwell· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

H. Yardimci

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2 papers

Recent·Most cited

Multivalent interactions essential for lentiviral integrase function

A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

bioRxiv · Jan 26, 2022Biochemistry

Single-molecule imaging reveals control of parental histone recycling by free histones during DNA replication

D. T. Gruszka, S. Xie, H. Kimura, H. Yardimci

The paper uses single-molecule imaging in Xenopus laevis egg extracts to show that most parental histones are evicted during DNA replication, with histone recycling and nucleosome sliding occurring less frequently.

bioRxiv · Oct 1, 2019Biophysics