Author

V. E. Pye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Nans· 2 shared P. Cherepanov· 2 shared A. Ballandras-Colas· 1 shared A. Costa· 1 shared A. N. Engelman· 1 shared D. J. Griffiths· 1 shared D. Lyumkis· 1 shared D. P. Maskell· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. Nans

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Author profile →

2 papers

Recent·Most cited

Multivalent interactions essential for lentiviral integrase function

A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

bioRxiv · Jan 26, 2022Biochemistry

Retroviral integration into nucleosomes throughDNA looping and sliding along the histone octamer

M. D. Wilson, L. Renault, D. P. Maskell, M. Ghoneim, V. E. Pye, A. Nans, D. S. Rueda, P. Cherepanov, A. Costa

This study reveals that retroviral integrase uses a looping-and-sliding mechanism to reposition nucleosomal DNA for integration, similar to chromatin remodelers.

bioRxiv · Jun 7, 2019Biochemistry