Zinc intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC
L. H. Lefrancois, V. Kalinina, E. Cardenal-Munoz, N. Hanna, H. Koliwer-Brandl, J. Appiah, F. Leuba, H. Hilbi, T. Soldati, C. Barisch
This study shows that M. marinum infection induces Zn2+ accumulation in D. discoideum phagosomes, which is counteracted by bacterial upregulation of the Zn2+ exporter CtpC.
bioRxiv · Mar 15, 2019Cell Biology