Author

L. H. Lefrancois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

T. Soldati· 3 shared C. Barisch· 2 shared J. Appiah· 2 shared N. Hanna· 2 shared V. Kalinina· 2 shared E. Cardenal-Munoz· 1 shared F. Leuba· 1 shared G. Panis· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

T. Soldati

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3 papers

Recent·Most cited

Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals genetic requirement for virulence and survival in amoebae and microglial cells

L. H. Lefrancois, J. Nitschke, G. Panis, J. Prados, R. E. Butler, T. A. Mendum, N. Hanna, G. R. Stewart, T. Soldati

This study uses Tn-Seq to identify essential genes for Mycobacterium marinum survival in amoebae and microglial cells, revealing metabolic and virulence gene requirements during infection.

bioRxiv · Mar 22, 2023Microbiology

Zinc intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC

L. H. Lefrancois, V. Kalinina, E. Cardenal-Munoz, N. Hanna, H. Koliwer-Brandl, J. Appiah, F. Leuba, H. Hilbi, T. Soldati, C. Barisch

This study shows that M. marinum infection induces Zn2+ accumulation in D. discoideum phagosomes, which is counteracted by bacterial upregulation of the Zn2+ exporter CtpC.

bioRxiv · Mar 15, 2019Cell Biology

Think zinc: Role of zinc poisoning in the intraphagosomal killing of bacteria by the amoeba Dictyostelium

C. Barisch, V. Kalinina, L. H. Lefrancois, J. Appiah, T. Soldati

The paper investigates zinc poisoning as a bactericidal strategy in Dictyostelium by studying zinc transporters and their role in phagosome zinc accumulation.

bioRxiv · Jun 27, 2018Cell Biology