Author

V. L. Alonso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

A. Pezza· 2 shared E. C. Serra· 2 shared E. Rodriguez Araya· 2 shared F. Calderon· 2 shared L. E. Tavernelli· 2 shared C. Silva Goncalves· 1 shared E. Serra· 1 shared G. Martinez Peralta· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

A. Pezza

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay

E. C. Serra, L. Tavernelli, V. L. Alonso, I. Pena, E. Rodriguez Araya, R. Manarin, J. Cantizani, J. Martin, J. Salamanca, P. Bamborough, F. Calderon, R. Gabarro

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

bioRxiv · Feb 16, 2024 · PreprintMicrobiology

Ultrastructure Expansion Microscopy (U-ExM) in Trypanosoma cruzi: localization of tubulin isoforms and isotypes

V. L. Alonso

The paper validates Ultrastructure Expansion Microscopy (U-ExM) in Trypanosoma cruzi, quantifies expansion factors, and localizes tubulin isoforms and isotypes across life cycle stages.

bioRxiv · Mar 6, 2022Cell Biology

Essential bromodomain TcBDF2 as a drug target against Chagas disease

A. Pezza, L. E. Tavernelli, V. L. Alonso, V. G. Perdomo, R. C. Gabarro, R. Prinjha, E. Rodriguez Araya, I. Rioja, R. Docampo, F. Calderon, J. J. Martin, E. Serra

This paper identifies TcBDF2 as an essential bromodomain protein in Trypanosoma cruzi, showing its role in parasite survival and pathogenesis, and demonstrates its potential as a drug target.

bioRxiv · Jan 25, 2022Cell Biology

Alpha-tubulin acetylation in Trypanosoma cruzi: a dynamic instability of microtubules is required for replication and cell cycle progression

V. L. Alonso, M. E. Carloni, C. Silva Goncalves, G. Martinez Peralta, M. E. Chesta, A. Pezza, L. E. Tavernelli, M. C. Machado Motta, E. C. Serra

This study shows that alpha-tubulin acetylation by TcATAT is essential for T. cruzi cell cycle progression and microtubule stability, with over-expression causing cell cycle arrest and drug resistance.

bioRxiv · Dec 15, 2020Cell Biology