Author

R. Gabarro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1

Frequent Co-Authors

F. Calderon· 3 shared A. J. Wilkinson· 2 shared J. C. Mottram· 2 shared J. Martin· 2 shared N. G. Jones· 2 shared C. N. Russell· 1 shared E. C. Serra· 1 shared E. Rodriguez Araya· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

F. Calderon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay

E. C. Serra, L. Tavernelli, V. L. Alonso, I. Pena, E. Rodriguez Araya, R. Manarin, J. Cantizani, J. Martin, J. Salamanca, P. Bamborough, F. Calderon, R. Gabarro

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

bioRxiv · Feb 16, 2024 · PreprintMicrobiology

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

C. N. Russell, J. L. Carter, J. M. Borgia, J. Bush, F. Calderon, R. Gabarro, S. J. Conway, J. C. Mottram, A. J. Wilkinson, N. G. Jones

This paper identifies LdBDF5 as a potential drug target for antileishmanial therapy by showing its interaction with human bromodomain inhibitors and demonstrating antipromastigote activity of SGC-CBP30.

bioRxiv · Aug 21, 2023Biochemistry

Bromodomain factor 5 is an essential transcriptional regulator of the Leishmania genome.

N. G. Jones, V. Geoghegan, G. Moore, J. B. T. Carnielli, K. Newling, F. Calderon, R. Gabarro, J. Martin, R. Prinjha, I. Rioja, A. J. Wilkinson, J. C. Mottram

This study identifies BDF5 as essential for Leishmania gene expression and survival by analyzing its role in chromatin interpretation and transcriptional regulation.

bioRxiv · Sep 29, 2021Cell Biology