Author

V. L. Ruiz-Perez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Lamuedra· 1 shared A. Mediero· 1 shared A. Palencia-Campos· 1 shared B. R. Myers· 1 shared C. C. King· 1 shared C. D. Arveseth· 1 shared C. Olivieri· 1 shared D. Bertinetti· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPathology

A. Lamuedra

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2 papers

Recent·Most cited

Blocking chondrocyte hypertrophy in conditional Evc knockout mice does not modify osteoarthritis progression

A. Lamuedra, P. Gratal, L. Calatrava, V. L. Ruiz-Perez, A. Palencia-Campos, S. Portal-Nunez, A. Mediero, G. Herrero-Beaumont, R. Largo

This study investigates whether Evc deletion prevents OA progression by inhibiting chondrocyte hypertrophy, finding partial prevention of hypertrophy but no improvement in cartilage damage.

bioRxiv · Oct 29, 2021 · PreprintPathology

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. L. Ruiz-Perez, G. Veglia, F. W. Herberg, , B. R. Myers

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

bioRxiv · Jul 5, 2021Biochemistry