Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model
H. C. Brown, S. Beck, S. Navarro, Y. Di, E. M. Soriano Jerez, J. Kaczmarzyk, S. G. Thomas, V. Mirakaj, S. P. Watson, B. Nieswandt, D. Stegner
This paper develops a humanised CLEC-2 mouse model and a monoclonal antibody to test anti-CLEC-2 therapeutics, showing transient thrombocytopenia without affecting haemostasis.
bioRxiv · Oct 3, 2021 · PreprintPhysiology