PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.
A. Poli, F. A. Pennacchio, P. Nastaly, A. Ghisleni, M. Crestani, F. M. Pramotton, F. Iannelli, G. Beznusenko, A. A. Mironov, V. Panzetta, S. Fusco, B. Sheth, N. Paolo, D. Poulikakos, A. Ferrari, , P. Maiuri
The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.
bioRxiv · Mar 25, 2022 · PreprintCell Biology