Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis
F. A. Pennacchio, A. Poli, F. M. Pramotton, S. Lavore, I. Rancati, M. Cinquanta, D. Vorselen, E. Prina, O. M. Romano, A. Ferrari, M. Piel, M. Cosentino Lagomarsino, P. Maiuri
The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.
bioRxiv · Jun 7, 2022 · PreprintCell Biology