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5 papers
Recent·Most cited
M. Bonilla-Quintana, A. Ghisleni, N. C. Gauthier, P. Rangamani
This paper develops a network model of the membrane skeleton integrating myosin and membrane mechanics to show that membrane bending and spectrin/myosin turnover are critical for maintaining structural stability under mechanical stress.
bioRxiv · Apr 29, 2024Biophysics
A. Ghisleni, M. Bonilla-Quintana, M. Crestani, A. Fukuzawa, P. Rangamani, N. Gauthier
This study shows spectrin in mammalian cells can transition between different topological structures under mechanical stress, adapting to protect the cell cortex.
bioRxiv · Jan 2, 2023 · PreprintCell Biology
A. Poli, F. A. Pennacchio, P. Nastaly, A. Ghisleni, M. Crestani, F. M. Pramotton, F. Iannelli, G. Beznusenko, A. A. Mironov, V. Panzetta, S. Fusco, B. Sheth, N. Paolo, D. Poulikakos, A. Ferrari, , P. Maiuri
The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.
bioRxiv · Mar 25, 2022 · PreprintCell Biology
P. Monzo, M. Crestani, Y. K. Chong, K. Hennig, A. Ghisleni, Q. Li, C. Richichi, P. Maiuri, M. Balland, M. P. Sheetz, G. Pelicci, B. T. Ang, C. Tang, N. C. Gauthier
The paper identifies FMN1 as a driver of glioblastoma invasiveness by linking it to increased cell stiffness, mechanical forces, and stochastic motility.
bioRxiv · Jun 17, 2020Cell Biology
A. Ghisleni, C. Galli, P. Monzo, F. Ascione, M. A. Fardin, G. Scita, Q. Li, P. Maiuri, N. Gauthier
The paper investigates how spectrin and acto-myosin cytoskeletons dynamically reorganize during mechanical challenges to support membrane territories.
bioRxiv · Dec 11, 2019Cell Biology