Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS
A. Kalvala, P. Wallet, L. Yang, C. Wang, H. Li, A. Nam, A. Nathan, I. Mambetsariev, V. Poroyko, H. Gao, P. Chu, M. Sattler, A. Bild, E. R. Manuel, P. P. Lee, , R. Salgia
The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.
bioRxiv · Sep 11, 2019Cancer Biology