P. P. Lee

Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood

The paper profiles cytokine signaling responses in breast cancer patients and finds coordinated dysregulation across pathways and cell types, suggesting immune cell reprogramming and immunosuppression.

PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages

This study shows that PD-L1 blockade enhances CAR T cell activity by altering macrophage phenotypes through IFNγ signaling in the tumor microenvironment.

A minimal model of T cell avidity may identify subtherapeutic vaccine schedules

This paper develops a minimal mathematical model of T cell avidity to identify vaccine schedules that favor low-avidity T cells by analyzing parameter sensitivity and clinical data.

Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

This paper shows ivermectin converts cold tumors to hot by inducing immunogenic cancer cell death and enhancing T cell infiltration, synergizing with anti-PD1 to improve breast cancer treatment outcomes.

NLRP3 inflammasome contributes to host defense against Talaromyces marneffei infection

This study shows that NLRP3 inflammasome activation is critical for host defense against Talaromyces marneffei infection by promoting IL-1β production and Th1/Th17 responses.

Immature dendritic cells promote high avidity tuning of vaccine T cell response

This study shows that immature dendritic cells can enhance high-avidity T cell responses to vaccines by reducing peptide:MHC complex load.

Arhgap25 deficiency leads to decreased numbers of peripheral blood B cells and defective germinal center reactions

This study shows that Arhgap25 deficiency in mice reduces peripheral B cell numbers and impairs germinal center formation and IgG1 class switching.

Selective Ablation of Cancer Cells with Low Intensity Pulsed Ultrasound

This study demonstrates that low intensity pulsed ultrasound selectively disrupts cancer cells by exploiting their distinct mechanical properties, offering a safer alternative to high intensity ultrasound ablation.

Phenotypic Switching of Naïve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

Fractal dimension, occupancy and hotspot analyses of B cell spatial distribution predict clinical outcome in breast cancer

The paper analyzes the spatial distribution of B cells in breast cancer tumors using novel statistical methods and finds that their spatial arrangement correlates with clinical outcomes.

Cell non-autonomous interactions during non-immune stromal progression in the breast tumor microenvironment

The paper analyzes non-immune stromal gene expression in breast tumors across different stages and identifies gene expression patterns associated with cancer progression and clinical outcomes.

On the mechanism of long-range alignment order of fibroblasts

This study investigates the mechanism behind long-range alignment of fibroblasts, showing that local interactions are insufficient and proposing a non-local interaction involving the extracellular matrix.