CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling
V. Rubino, M. Hueppi, S. Hoepner, L. Tortola, L. Taylor, I. Keller, R. Bruggmann, M.-N. Kronig, U. V. Bacher, M. Kopf, A. Ochsenbein, C. Riether
This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.
bioRxiv · Sep 1, 2023 · PreprintCancer Biology