Author

I. Keller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 6 Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Assay:proteomics· 4 Organism:Arabidopsis· 3 Research Focus:development & morphogenesis· 3 Organism:human· 3 Organism:mouse· 3

Frequent Co-Authors

B. Pommerrenig· 5 shared H. E. Neuhaus· 5 shared A. Khan· 2 shared C. Martins Rodrigues· 2 shared C. Müdsam· 2 shared F. Ludewig· 2 shared K. Harms· 2 shared M. Schroda· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersPlant Biology

B. Pommerrenig

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Ribonuclease Inhibitor and Angiogenin collaboratively regulate cell-type-specific global translation

M. Stillinovic, M. A. Sarangdhar, N. Andina, A. Tardivel, F. Greub, G. Bombaci, C. Ansermet, M. Heller, A. Keogh, I. Keller, A. Angelillo-Scherrer, R. Allam

This study identifies RNH1 and ANG as regulators of cell-type-specific global translation, showing RNH1 affects hematopoietic cells while ANG protects non-hematopoietic cells.

bioRxiv · Mar 29, 2024 · PreprintBiochemistry

Neuronal substance-P drives breast cancer growth and metastasis via an extracellular RNA/TLR7 axis

V. Padmanaban, I. Keller, E. S. Seltzer, B. N. Ostendorf, Z. Kerner, S. F. Tavazoie

This study identifies neuronal substance-P as a driver of breast cancer growth and metastasis through an extracellular RNA/TLR7 signaling axis, with therapeutic targeting showing efficacy in mouse models.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

V. Rubino, M. Hueppi, S. Hoepner, L. Tortola, L. Taylor, I. Keller, R. Bruggmann, M.-N. Kronig, U. V. Bacher, M. Kopf, A. Ochsenbein, C. Riether

This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

Carbohydrate distribution via SWEET17 is critical for Arabidopsis inflorescence branching under drought

M. Valifard, A. Khan, R. LE HIR, B. Pommerrenig, H. E. Neuhaus, I. Keller

The paper identifies SWEET17's role in carbohydrate distribution to support inflorescence branching under drought stress in Arabidopsis.

bioRxiv · Jan 10, 2023Plant Biology

The vacuolar sugar transporter EARLY RESPONSE TO DEHYDRATION 6-LIKE4 regulates fructose signaling and plant growth

A. Khan, J. Cheng, A. Kitashova, L. Fürtauer, T. Nägele, C. Picco, J. Scholz-Starke, I. Keller, H. E. Neuhaus, B. Pommerrenig

The paper shows that ERDL4 regulates fructose homeostasis, affecting plant growth and cold tolerance in Arabidopsis.

bioRxiv · Dec 21, 2022 · PreprintPlant Biology

PPAR-γ regulates the effector function of human TH9 cells by promoting glycolysis

N. L. Bertschi, O. Steck, F. Luther, C. Bazzini, L. von Meyenn, A. Felser, I. Keller, O. Friedli, S. Freigang, N. Begre, C. Lamos, M. P. Gabutti, M. Benzaquen, M. Laimer, D. Simon, , C. Schlapbach

This study shows PPAR-γ promotes glycolysis in human TH9 cells, enhancing IL-9 expression and effector function through mTORC1.

bioRxiv · Aug 16, 2022 · PreprintImmunology

Cold-triggered induction of ROS- and raffinose metabolism in freezing-sensitive taproot tissue of sugar beet

I. Keller, C. Müdsam, C. Martins Rodrigues, D. Kischka, W. Zierer, U. Sonnewald, K. Harms, O. Czarnecki, K. Fiedler-Wiechers, W. Koch, H. E. Neuhaus, F. Ludewig, B. Pommerrenig

The paper compares freezing responses in sugar beet genotypes with different tolerance levels, finding that raffinose and its precursors accumulate in pith tissue of tolerant genotypes, suggesting a protective role against freezing damage.

bioRxiv · Apr 12, 2021Plant Biology

Nucleotide limitation results in impaired photosynthesis, reduced growth and seed yield together with massively altered gene expression

L. Bellin, M. Melzer, A. Hilo, D. L. G. Amaya, I. Keller, J. Meurer, T. Möhlmann

The paper shows that nucleotide limitation from impaired pyrimidine synthesis impairs photosynthesis, growth, seed yield, and causes widespread gene expression changes in plants.

bioRxiv · Jan 22, 2021Plant Biology

Vernalization alters sugar beet (Beta vulgaris) sink and source identities and reverses phloem translocation from taproots to shoots

C. Martins Rodrigues, C. Müdsam, I. Keller, W. Zierer, O. Czarnecki, J. M. Corral, F. Reinhardt, P. Nieberl, F. Sommer, M. Schroda, T. Mühlhaus, K. Harms, U.-I. Flügge, W. Koch, F. Ludewig, , B. Pommerrenig

This study shows vernalization in sugar beets reverses sink-source dynamics by altering phloem translocation and gene expression, leading to sugar remobilization from taproots to shoots.

bioRxiv · Jan 28, 2020Plant Biology

Identification of chloroplast envelope proteins with critical importance for cold acclimation

O. Trentmann, T. Mühlhaus, D. Zimmer, F. K. Sommer, M. Schroda, I. Haferkamp, I. Keller, B. Pommerrenig, H. E. Neuhaus

The paper identifies chloroplast envelope proteins critical for cold acclimation in Arabidopsis thaliana using proteomics and mutant analysis.

bioRxiv · Oct 21, 2019Plant Biology