Inhibition of SARS-CoV-2 infection in human cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoskeleton architecture and contractility
J. A. Salerno, T. Torquato, J. R. Temerozo, L. Goto-Silva, M. A. Mendes, C. Q. Sacramento, N. Fintelman-Rodrigues, G. Vitoria, L. R. Q. Souza, I. M. Ornelas, C. Verissimo, K. Karmirian, C. d. S. G. Pedrosa, S. d. S. G. Dias, V. C. Soares, , S. Rehen
This study shows that inhibiting the Sigma-1 receptor with NE-100 reduces SARS-CoV-2 infection in human cardiomyocytes but also impairs cytoskeleton and contractility.
bioRxiv · Feb 20, 2021 · PreprintCell Biology