Author

L. Goto-Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

S. Rehen· 4 shared C. Q. Sacramento· 3 shared G. Vitoria· 3 shared I. M. Ornelas· 3 shared J. A. Salerno· 3 shared J. R. Temerozo· 3 shared K. Karmirian· 3 shared L. R. Q. Souza· 3 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

S. Rehen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Proteomic changes induced by harmine in human brain organoids reveal signaling pathways related to neuroprotection

K. Karmirian, L. Goto-Silva, J. M. Nascimento, M. N. Costa, J. A. Salerno, I. M. Ornelas, B. Vanderborght, D. Martins-de-Souza, S. Rehen

This study identifies proteomic changes in human brain organoids treated with harmine, revealing pathways linked to neuroprotection such as synaptic vesicle cycle and neurotrophin signaling.

bioRxiv · Jun 16, 2021 · PreprintCell Biology

WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2

L. G. H. S. Aragao, J. T. Oliveira, J. R. Temerozo, M. A. Mendes, J. A. Salerno, C. d. S. G. Pedrosa, T. Puig-Pijuan, C. Verissimo, I. M. Ornelas, T. Torquato, G. Vitoria, C. Q. Sacramento, N. Fintelman-Rodrigues, S. d. S. G. Dias, V. Cardoso Soares, , S. Rehen

This study examines the effects of the cannabinoid agonist WIN 55,212-2 on inflammation and cell survival in human iPSC-derived cardiomyocytes infected with SARS-CoV-2, finding reduced cytokine levels and cytotoxic damage.

bioRxiv · Feb 20, 2021 · PreprintCell Biology

Inhibition of SARS-CoV-2 infection in human cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoskeleton architecture and contractility

J. A. Salerno, T. Torquato, J. R. Temerozo, L. Goto-Silva, M. A. Mendes, C. Q. Sacramento, N. Fintelman-Rodrigues, G. Vitoria, L. R. Q. Souza, I. M. Ornelas, C. Verissimo, K. Karmirian, C. d. S. G. Pedrosa, S. d. S. G. Dias, V. C. Soares, , S. Rehen

This study shows that inhibiting the Sigma-1 receptor with NE-100 reduces SARS-CoV-2 infection in human cardiomyocytes but also impairs cytoskeleton and contractility.

bioRxiv · Feb 20, 2021 · PreprintCell Biology

The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2

C. Q. Sacramento, N. Fintelman-Rodrigues, J. R. Temerozo, A. d. P. D. Da Silva, S. da Silva Gomes Dias, A. C. Ferreira, C. d. S. da Silva, M. Mattos, C. R. R. Pao, C. S. de Freitas, V. Cardoso Soares, L. V. B. Hoelz, T. V. A. Fernandes, F. S. C. Branco, M. M. Bastos, , T. M. L. Souza

This study evaluates the antiviral activity of daclatasvir and sofosbuvir against SARS-CoV-2 in vitro, showing inhibition of viral replication and associated pathologies.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome

L. Goto-Silva, M. P. McShane, S. Salinas, Y. Kalaidzidis, G. Schiavo, M. Zerial

The paper identifies Rab5-APPL1 endosomes as mediators of retrograde Akt1 transport in hippocampal pyramidal neurons.

bioRxiv · Dec 17, 2018Cell Biology

Computational fluid dynamic analysis reveals the underlying physical forces playing a role in 3D multiplex brain organoid cultures

L. Goto-Silva, N. Ayad, I. Herzog, N. Silva, B. Lamien, H. Orlande, A. da Costa Souza, S. Ribeiro, M. Martins, G. Domont, M. Junqueira, F. Tovar-Moll, S. Rehen

The paper uses computational fluid dynamics to compare multiplex brain organoid culture systems and finds that steering plates match spinner flask shear stress parameters, improving organoid formation.

bioRxiv · Jul 13, 2018Bioengineering