Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses
Enquan Xu, Ravindra Boddu, Hisham Abdelmotilib, Kaela Kelly, Arpine Sokratian, Ashley S. Harms, Aubrey M Schonhoff, Nicole Bryant, Irene E. Harmsen, Michael G. Schlossmacher, Sidhanth Chandra, Valentina Krendelshchikova, Zhiyong Liu, Andrew B. West
The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.
bioRxiv · May 4, 2020 · PreprintNeuroscience