RNA-DNA triplex-forming miRNAs define an evolutionarily recent chromatin regulatory mechanism
Michell Martin, Consuelo Jalife, Catalina Méndez, Cristian Montecinos, David A. Brown‐Brown, Francisca Díaz-Tejeda, Valeria Caffi, Kattina Zavala, Fabian Kugler, Loreto Molina-Gonzalez, Guillermo Valenzuela, Gernot Längst, Gonzalo Antonio Mardones, Roberto Munita, Juan C. Opazo, R. Maldonado
The paper identifies RNA-DNA triplex-forming miRNAs in human cells and shows they are evolutionarily recent and associated with Ago2-chromatin interactions.
bioRxiv · Jun 5, 2026 · PreprintMolecular Biology