Guillermo Valenzuela

RNA-DNA triplex-forming miRNAs define an evolutionarily recent chromatin regulatory mechanism

The paper identifies RNA-DNA triplex-forming miRNAs in human cells and shows they are evolutionarily recent and associated with Ago2-chromatin interactions.

A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape

This paper develops a bispecific antibody that targets both Nipah virus surface glycoproteins, reducing viral escape and enhancing protection against NiV disease.

Novel Library Assembly Technique for Developing Nanobodies Targeting IPNv VP2 Protein

This paper develops a novel nanobody library assembly technique for targeting IPNv VP2 protein, identifying specific nanobodies with diagnostic potential.

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity Nanobody.

The paper describes the development of a high-affinity Nanobody against SARS-CoV-2 RBD that neutralizes wild-type and D614G variants with nanomolar potency.