Blocking Minor Intron Splicing Disrupts DNA Repair and Overcomes Therapy Resistance in Prostate and Breast Cancer
Anke Augspach, Paola Francica, Kaitlin N. Girardini, Muriel Jaquet, Marika Lehner, Antonio Rodríguez-Calero, Charlotte Komarek, Martín González-Fernández, Hannah Williams, Xiaoyue Deng, Lea Lingg, Cristina Zivko, Vera Fuchs, Seynabou Diop, Sina Maletti, , Mark A. Rubin
This study shows that targeting the minor spliceosome, specifically U6atac snRNA, disrupts DNA repair and overcomes therapy resistance in prostate and breast cancers.
bioRxiv · Dec 13, 2025 · PreprintCancer Biology