Developmental control of DNA damage responses in α- and β-cells shapes the selective beta-cell susceptibility in diabetes
Sneha S. Varghese, Alessandro Giovanni Hernandez-De La Peña, Liu Wang, Victor Ruiz, Wilma Tixi, Aparamita Pandey, Laura M. Anchondo, Amy Chiu, Xiwei Wu, Senta K. Georgia, Hung-Ping Shih, Zong Wei, S. Bhattacharya, Sangeeta Dhawan
The paper investigates how developmental DNA damage responses in α- and β-cells contribute to their differential susceptibility to diabetes, showing β-cells have higher DNA damage vulnerability and repair efficiency.
Diabetes · Jul 15, 2026Peer-reviewedDevelopmental Biology