Xiwei Wu

This study shows that targeting the TGFβ pathway improves CAR T cell efficacy in glioblastoma by enhancing antitumor activity and modulating the tumor microenvironment.

The paper uses long-read sequencing to identify novel lncRNAs generated by SF3B1 mutation and shows they produce functional peptides linked to cancer prognosis.

This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

The paper investigates how developmental DNA damage responses in α- and β-cells contribute to their differential susceptibility to diabetes, showing β-cells have higher DNA damage vulnerability and repair efficiency.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

The paper identifies DNA replication errors as a source of small inverted triplication (SIT) structural variants in yeast, showing their formation mechanism and characteristics.

This study shows that knocking down the long isoform of the prolactin receptor reduces pathogenic immune cells and prevents lupus nephritis in SLE-prone mice.

This study identifies immunometabolic factors in CD19 CAR T cells that predict long-term response in B-ALL patients and suggests mTOR inhibition as a strategy to enhance anti-tumor activity.

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

This study identifies SPP1+ macrophages as key drivers of resistance to CAR T therapy in solid tumors and shows that targeting SPP1 can overcome this resistance.

The paper evaluates differential expression methods in bulk RNA-Seq by comparing edgeR-robust and DESeq2 in cell line and cancer data, highlighting the need for method testing in genomics projects.

PENCIL identifies phenotype-relevant cell subpopulations from single-cell data using a supervised learning framework with feature selection and trajectory prediction capabilities.

This study identifies DNA methylation as a mechanism restricting TH+ β-cell subpopulation in pancreatic islets, showing its role in β-cell heterogeneity and identity maintenance.

This study identifies nine epitopes on EBV gp350, including two novel neutralizing epitopes, through monoclonal antibody analysis and epitope mapping.