Senta K. Georgia

Developmental control of DNA damage responses in α- and β-cells shapes the selective beta-cell susceptibility in diabetes

The paper investigates how developmental DNA damage responses in α- and β-cells contribute to their differential susceptibility to diabetes, showing β-cells have higher DNA damage vulnerability and repair efficiency.

Bright Probes, Blurred Metabolism: Navigating Fluorescent Protein Cross-Excitation in NADH FLIM

This paper evaluates cross-talk between fluorescent proteins and NADH FLIM, identifying compatible FPs and providing a pipeline to manage cross-excitation in metabolic imaging.

Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling

This study shows secretory stimuli induce distinct structural changes in insulin secretory granules, affecting their maturation and subcellular distribution in beta-cells.

Multiscale Light Field Microscopy Platform for Multi-purpose Dynamic Volumetric Bioimaging

This paper introduces a multiscale light field microscopy platform for fast 3D imaging across biological scales, demonstrating its use in whole-brain activity, calcium dynamics, and subcellular protein dynamics.

DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity

This study identifies DNA methylation as a mechanism restricting TH+ β-cell subpopulation in pancreatic islets, showing its role in β-cell heterogeneity and identity maintenance.

Systematic Bayesian posterior analysis guided by Kullback-Leibler divergence facilitates hypothesis formation

This paper introduces a KL divergence-based Bayesian framework to systematically rank parameters for hypothesis formation, demonstrating its effectiveness in two computational models.

Phosphatases are predicted to govern prolactin-mediated JAK-STAT signaling in pancreatic beta cells

The paper uses a computational model to show that phosphatase concentrations and prolactin receptor levels influence JAK-STAT signaling in pancreatic beta cells, suggesting targets for diabetes treatment.

Dynamic regulation of JAK-STAT signaling through the prolactin receptor predicted by computational modeling

The paper develops a computational model of JAK-STAT signaling through the prolactin receptor in beta cells, showing that receptor upregulation and regulatory modules are needed to match experimental STAT5 dynamics.