Paralemmin-3 sustains the integrity of the lateral plasma membrane and subsurface cisternae of auditory hair cells
Victoria C. Halim, Iman Bahader, Dennis Derstroff, Christina Ullrich, Makoto F. Kuwabara, Greta Hultqvist, Kathrin Kusch, Loujin Slitin, Lore Becker, Martin Hrabě de Angelis, Carolin Wichmann, Dominik Oliver, Nicola Strenzke, Christian Vogl, Manfred W. Kilimann
This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.
bioRxiv · Jul 11, 2025 · PreprintCell Biology