Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS
Neeraja Purandare, Vignesh Pasupathi, Yue Xi, Vikram Rajan, Caleb Vegh, Steven M. Firestine, Tamás Kozicz, Andrew M. Fribley, Lawrence I. Grossman, Siddhesh Aras
The paper identifies nitazoxanide and tizoxanide as compounds that increase MNRR1 levels, improving mitochondrial function in MELAS by inhibiting HIF2α-mediated transcriptional suppression.
bioRxiv · Oct 7, 2024 · PreprintMolecular Biology