Lawrence I. Grossman

Mitochondrial COX4I2 drives pericyte-dependent inflammation and emphysema

This study shows that COX4I2 in pericytes drives inflammation and emphysema in COPD by increasing mtROS, and its deletion protects against these effects.

MNRR1 is required for Triple Negative Breast Cancer growth and metastasis and can be targeted by repurposed drugs.

This study identifies MNRR1 as a critical driver of TNBC growth and metastasis, showing it can be targeted by existing drugs.

Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides

This paper shows MNRR1 activates transcription by recruiting p300 and that minimal peptides can enhance this activity.

Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS

The paper identifies nitazoxanide and tizoxanide as compounds that increase MNRR1 levels, improving mitochondrial function in MELAS by inhibiting HIF2α-mediated transcriptional suppression.

Lipopolysaccharide induces placental mitochondrial dysfunction by reducing MNRR1 levels via a TLR4-independent pathway

This study shows that lipopolysaccharide reduces MNRR1 levels in placental tissues, leading to mitochondrial dysfunction and inflammation via a TLR4-independent pathway.