Neeraja Purandare

This study identifies MNRR1 as a critical driver of TNBC growth and metastasis, showing it can be targeted by existing drugs.

This paper shows MNRR1 activates transcription by recruiting p300 and that minimal peptides can enhance this activity.

This study identifies that vemurafenib resistance in BRAFV600E melanomas is linked to metabolic pathway choices and Wnt/β-catenin signaling, with varying tolerance thresholds affecting mitochondrial and pentose phosphate pathway utilization.

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

The paper identifies nitazoxanide and tizoxanide as compounds that increase MNRR1 levels, improving mitochondrial function in MELAS by inhibiting HIF2α-mediated transcriptional suppression.

This study shows that lipopolysaccharide reduces MNRR1 levels in placental tissues, leading to mitochondrial dysfunction and inflammation via a TLR4-independent pathway.