Author

Vignesh Pasupathi

Wayne State UniversityORCID 0000-0002-3477-4659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lawrence I. GrossmaniD· 3 shared Neeraja PurandareiD· 3 shared Siddhesh ArasiD· 3 shared Andrew M. FribleyiD· 2 shared Caleb VeghiD· 2 shared Sagarika Rai· 2 shared Yue XiiD· 2 shared Adi Laurentiu TarcaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

Lawrence I. GrossmanORCID

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3 papers

Recent·Most cited

MNRR1 is required for Triple Negative Breast Cancer growth and metastasis and can be targeted by repurposed drugs.

Mrunal Sathe, Paige M. Minchella, Caleb Vegh, Mithra Modikuppam Dharmalingam, Vignesh Pasupathi, Yue Xi, Sagarika Rai, Mrunmayee Patil, Habiba Elshenawy, Sydney Rudolph, Gaurav Bhatti, Adi Laurentiu Tarca, Neeraja Purandare, Andrew M. Fribley, Lawrence I. Grossman, Siddhesh Aras

This study identifies MNRR1 as a critical driver of TNBC growth and metastasis, showing it can be targeted by existing drugs.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides

Neeraja Purandare, Vignesh Pasupathi, Deepesh Kumar Padhan, Sagarika Rai, Lawrence I. Grossman, Siddhesh Aras

This paper shows MNRR1 activates transcription by recruiting p300 and that minimal peptides can enhance this activity.

Mitochondrion · Jan 25, 2026Peer-reviewedCell Biology

Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS

Neeraja Purandare, Vignesh Pasupathi, Yue Xi, Vikram Rajan, Caleb Vegh, Steven M. Firestine, Tamás Kozicz, Andrew M. Fribley, Lawrence I. Grossman, Siddhesh Aras

The paper identifies nitazoxanide and tizoxanide as compounds that increase MNRR1 levels, improving mitochondrial function in MELAS by inhibiting HIF2α-mediated transcriptional suppression.

bioRxiv · Oct 7, 2024 · PreprintMolecular Biology